Pharmacological Reports 2010, 62, 1?14 ISSN 1734-1140 Copyright © 2010 by cost of Pharmacology Polish Academy of Sciences Review Huntingtons disorder: pathogenesis to animal(prenominal) models Puneet Kumar, Harikesh Kalonia, Anil Kumar Pharmacology Division, University Institute of Pharmaceutical Sciences, UGC Centre of perish Study, Panjab University, Chandigarh-160014, India Correspondence: Anil Kumar e-mail: kumaruips@yahoo.com , Abstract: Huntingtons disease (HD) is an inherited genetic disorder, characterized by cognitive dysfunction and secondary body movements called chorea. George Huntington, an Ohio physician, described the disease precisely in 1872. HD is a dominantly inherited disorder, characterized by progressive neurodegeneration of the striatum but as well involves other regions, primarily the cerebral cortex. The mutation prudent for this dim disease is an abnormally expanded and unstable CAG relieve inside the coding region of the gene encoding the huntingtin protein. various(a) hypotheses accept been put forward to explain the pathogenic mechanisms of version huntingtin-induced neuronic dysfunction and cell death. None of these hypotheses, however, offers a take up interpretation; thus, it remains a topic of research interest.
HD is considered to be an principal(prenominal) disease, embodying many of the major themes in modern neuroscience, including molecular genetics, piercing neuronal vulnerability, excitotoxicity, mitochondrial dysfunction, apoptosis and transcriptional dysregulation. A number of recent reports endure concluded that oxidativ e stress plays a key unusual in HD pathoge! nesis. Although there is no specific treatment addressable to block disease progression, treatments are available to help in controlling the chorea symptoms. As animal models are the suck tools to evaluate any therapeutic agent, there are in addition different animal models available, mimicking a few or a larger number of symptoms. Each model has its stimulate advantages and limitations. The...If you regard to get a full essay, order it on our website:
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